Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

@article{Bhardwaj2007ResveratrolIP,
  title={Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.},
  author={Anjana Bhardwaj and Gautam Sethi and Saroj Vadhan-Raj and Carlos E Bueso-Ramos and Yasunari Takada and Upasna Gaur and Asha S Nair and Shishir Shishodia and Bharat Bhushan Aggarwal},
  journal={Blood},
  year={2007},
  volume={109 6},
  pages={
          2293-302
        }
}
Whether resveratrol, a component of red grapes, berries, and peanuts, could suppress the proliferation of multiple myeloma (MM) cells by interfering with NF-kappaB and STAT3 pathways, was investigated. Resveratrol inhibited the proliferation of human multiple myeloma cell lines regardless of whether they were sensitive or resistant to the conventional chemotherapy agents. This stilbene also potentiated the apoptotic effects of bortezomib and thalidomide. Resveratrol induced apoptosis as… CONTINUE READING

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