Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution.

@article{Ahmad2004ResveratrolID,
  title={Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution.},
  author={Kashif Adil Ahmad and Marie-V{\'e}ronique Cl{\'e}ment and Ismail Muhamad Hanif and Shazib Pervaiz},
  journal={Cancer research},
  year={2004},
  volume={64 4},
  pages={1452-9}
}
Efficient apoptotic signaling is a function of a permissive intracellular milieu created by a decrease in the ratio of superoxide to hydrogen peroxide and cytosolic acidification. Resveratrol (RSV) triggers apoptosis in some systems and inhibits the death signal in others. In this regard, the inhibitory effect on hydrogen peroxide-induced apoptosis is attributed to its antioxidant property. We provide evidence that exposure of human leukemia cells to low concentrations of RSV (4-8 micro M… CONTINUE READING