Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.

@article{Li2014ResveratrolIC,
  title={Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.},
  author={Ping Li and Mei-Lan Liang and Ying Zhu and Yao-Yao Gong and Yun Wang and Ding Heng and Lin Lin},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 16},
  pages={
          4648-61
        }
}
AIM To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms. METHODS Male Sprague-Dawley rats were randomly divided into two groups: a control group and a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis group. After 21 d of TNBS administration, the degree of inflammation and fibrosis in colon was measured by HE staining and… CONTINUE READING

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