Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.

Abstract

AIM To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms. METHODS Male Sprague-Dawley rats were randomly divided into two groups: a control group and a 2,4,6-trinitrobenzenesulfonic acid (TNBS… (More)
DOI: 10.3748/wjg.v20.i16.4648

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