Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells.

@article{MedinaAguilar2016ResveratrolIC,
  title={Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells.},
  author={Rubiceli Medina-Aguilar and Laurence A. Marchat and C Dai and Patricio Gariglio and Jaime Garc{\'i}a Mena and Nicol{\'a}s Villegas Sep{\'u}lveda and Macario Mart{\'i}nez Castillo and C{\'e}sar L{\'o}pez-Camarillo},
  journal={Oncology reports},
  year={2016},
  volume={35 6},
  pages={3696-704}
}
The Aurora protein kinase (AURKA) and the Polo-like kinase-1 (PLK1) activate the cell cycle, and they are considered promising druggable targets in cancer therapy. However, resistance to chemotherapy and to specific small‑molecule inhibitors is common in cancer patients; thus alternative therapeutic approaches are needed to overcome clinical resistance. Here, we showed that the dietary compound resveratrol suppressed the cell cycle by targeting AURKA and PLK1 kinases. First, we identified genes… CONTINUE READING

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