Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis.

@article{Wang2013ResveratrolIT,
  title={Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis.},
  author={Heyong Wang and Huijun Zhang and Liang Tang and Haixia Chen and Chunlian Wu and Mingchuan Zhao and Yaoqin Yang and Xiaofeng Chen and Gentao Liu},
  journal={Toxicology},
  year={2013},
  volume={303},
  pages={139-46}
}
Epithelial-to-mesenchymal transition (EMT) is a cellular process during which epithelial polarized cells become motile mesenchymal-appearing cells, which in turn promotes carcinoma invasion and metastasis. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenolic compound found in grapes, red wine and several other plants. Numerous reports in the literature indicate that resveratrol can suppress cancer invasion and metastasis. However, the underlying mechanisms of inhibiting… CONTINUE READING
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