Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro.

@article{Shakibaei2007ResveratrolII,
  title={Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro.},
  author={Mehdi Shakibaei and Thilo John and Claudia Seifarth and Ali Mobasheri},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1095},
  pages={554-63}
}
Resveratrol is a polyphenolic phytoalexin that is present in various fruits, in the skin of red grapes and peanuts. Recent studies have shown that resveratrol exhibits potent antioxidant properties and is able to exert anti-inflammatory and anti-catabolic properties in several cell types. The pro-inflammatory cytokine interleukin-1beta (IL-1beta) plays a pivotal role in the pathogenesis of osteoarthritis (OA) in humans and animals. In this article we investigated whether resveratrol is able to… CONTINUE READING
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