Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD(+)-dependent SIRT1 activity.

@article{Zhang2009ResveratrolIT,
  title={Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD(+)-dependent SIRT1 activity.},
  author={Hong-Sheng Zhang and Yue Zhou and Meng-Ran Wu and Hong-Sen Zhou and Fei Xu},
  journal={Life sciences},
  year={2009},
  volume={85 13-14},
  pages={484-9}
}
AIMS Tat protein plays a pivotal role in both the human immunodeficiency virus type 1 (HIV-1) replication cycle and the pathogenesis of HIV-1 infection. Sirtuins 1 (SIRT1) is a possible candidate for redox modulation because its activity is regulated by nicotinamide adenine dinucleotide (NAD(+)) or NAD(+)/NADH ratio. The aim of the present study was to determine whether the redox status and SIRT1 expression are related to HIV-1 Tat protein-induced transactivation. MAIN METHODS HeLa-CD4-long… CONTINUE READING

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