Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis.

@article{Demoulin2015ResveratrolID,
  title={Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis.},
  author={Benjamin Demoulin and Maryse Hermant and C{\'e}dric Castrogiovanni and Catherine Staudt and Patrick Dumont},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2015},
  volume={29 5},
  pages={1156-65}
}
Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenol synthesized by various plants such as grape vine. Resveratrol (RSV) is a widely studied molecule, largely for its chemopreventive effect in different mouse cancer models. We propose a mechanism underlying the cytotoxic activity of RSV on colon cancer cells. Our data show that resveratrol induces apoptosis, as observed by the cleavage of PARP-1 and chromatin condensation. We show that the tumor suppressor p53 is activated in… CONTINUE READING
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