Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells.

@article{Delmas2003ResveratrolinducedAI,
  title={Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells.},
  author={Dominique Delmas and C{\'e}dric R{\'e}b{\'e} and Sandrine Lacour and Rodolphe Filomenko and Anne Athias and Philippe Gambert and Mustapha Cherkaoui-Malki and Brigitte Jannin and Laurence Dubrez-Daloz and Norbert Latruffe and {\'E}ric Solary},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 42},
  pages={41482-90}
}
Resveratrol, a polyphenol found in grape skin and various other food products, may function as a cancer chemopreventive agent for colon and other malignant tumors and possesses a chemotherapeutic potential through its ability to trigger apoptosis in tumor cells. The present study analyses the molecular mechanisms of resveratrol-induced apoptosis in colon cancer cells, with special attention to the role of the death receptor Fas in this pathway. We show that, in the 10-100 microm range of… CONTINUE READING