Resveratrol in metabolic health: an overview of the current evidence and perspectives

@article{Poulsen2013ResveratrolIM,
  title={Resveratrol in metabolic health: an overview of the current evidence and perspectives},
  author={Morten M{\o}ller Poulsen and Jens Otto Lunde J{\o}rgensen and Niels Jessen and B Richelsen and Steen B{\o}nl{\o}kke Pedersen},
  journal={Annals of the New York Academy of Sciences},
  year={2013},
  volume={1290}
}
In the search for novel preventive and therapeutic modalities in the management of metabolic diseases and obesity, resveratrol has attracted great attention over the past decades. Preclinical trials suggest that resveratrol mimics the metabolic effects of calorie restriction (CR) via activation of silent mating type information regulation 2 homolog 1 (SIRT1). In experimental animals, this potential translates into prevention or improvement of glucose metabolism, anti‐inflammation, cancer, and… Expand
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Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats.
TLDR
Resveratrol improved dyslipidemia, hyperinsulinemia, hyperleptinemia and hypertension in obese Zucker rats, and produced anti-inflammatory effects in VAT, effects that seem to be mediated by AMPK activation. Expand
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
TLDR
It is reported that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels, and administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging. Expand
One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease.
TLDR
1-year consumption of a resveratrol-rich grape supplement improved the inflammatory and fibrinolytic status in patients who were on statins for primary prevention of CVD and at high CVD risk (i.e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor). Expand
Are sirtuins viable targets for improving healthspan and lifespan?
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The current status and controversies surrounding the potential of sirtuins as novel pharmacological targets are covered, with a focus on SIRT1. Expand
Resveratrol improves health and survival of mice on a high-calorie diet
TLDR
It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing. Expand
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
TLDR
Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR, andGene expression profiling suggests that both CR and resver atrol may retard some aspect of aging through alterations in chromatin structure and transcription. Expand
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
TLDR
It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife. Expand
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.
TLDR
It is shown for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resver atrol-induced decrease in oxidative stress that leads to a more efficient insulin signalling via the Akt pathway. Expand
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
TLDR
It is demonstrated that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction. Expand
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
TLDR
RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity. Expand
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