Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats.

  title={Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats.},
  author={Vincent Chan and Andrew Fenning and Abishek Iyer and Andrew Hoey and Lindsay Brown},
  journal={Current pharmaceutical biotechnology},
  volume={12 3},
The phytoalexin resveratrol (3,4',5-trihydroxy-trans-stilbene) may attenuate cardiovascular disease in man. This study has determined whether treatment with resveratrol (1 mg/kg/day orally) prevented cardiac fibrosis and the decreased cardiovascular function in the DOCA-salt hypertensive rat as a model of human hypertension. Uninephrectomised rats (UNX) administered DOCA (25mg every 4th day sc) and 1% NaCl in drinking water for 28 days developed cardiac and vascular remodelling. In these DOCA… CONTINUE READING


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