Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex

@article{Liu2016ResveratrolEA,
  title={Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex},
  author={Song Liu and Tong Li and Dexiang Liu and Xueer Wang and Shishi Bo and Yunkai Xie and Xuemei Bai and Lin Wu and Zhen Wang and Yuan Liu},
  journal={Behavioural Brain Research},
  year={2016},
  volume={302},
  pages={191-199}
}
Depression is one of the most common neuropsychiatric disorders and has been associated with oxidative stress and brain protein alterations. Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities including potent antidepressant-like effects. The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring oxidative stress parameters and phosphorylation of AKT/mTOR pathway in the rat… CONTINUE READING
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