Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells.

@article{Chen2007ResveratrolEI,
  title={Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells.},
  author={Wen-pin Chen and Tzong-Cherng Chi and Lee-Ming Chuang and M H Su},
  journal={European journal of pharmacology},
  year={2007},
  volume={568 1-3},
  pages={269-77}
}
The present study investigated the effect of resveratrol on the electrophysiology and insulin secretion of pancreatic beta cells, and examined resveratrol-induced alterations in insulin levels and plasma glucose of normal and streptozotocin-induced diabetic rats. Whole-cell voltage clamp study in the MIN6 cell, a mouse beta cell line, revealed that resveratrol significantly inhibited ATP-sensitive K(+) current at 3 micromol/l, and voltage-gated K(+) currents at 30 micromol/l. Ca(2+)-activated K… CONTINUE READING

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