Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis.

@article{Ma2015ResveratrolEA,
  title={Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis.},
  author={Lijie Ma and Wangping Li and Ruixuan Wang and Yandong Nan and Qingwei Wang and Wei Liu and Faguang Jin},
  journal={International journal of oncology},
  year={2015},
  volume={47 4},
  pages={
          1460-8
        }
}
Resveratrol is a plant-derived natural compound which possesses potential anticancer properties. However, there are scarce reports on its anticancer effects in non-small cell lung cancer and its auxiliary function on the anticancer effects of cisplatin. In the present study, we investigated the effects of resveratrol on the cell viability and apoptosis in human non-small cell lung cancer H838 and H520 cell lines. It has been found that resveratrol inhibited the proliferation of H838 and H520… 
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Resveratrol promotes the sensitivity of small-cell lung cancer H446 cells to cisplatin by regulating intrinsic apoptosis.
TLDR
It is suggested that resveratrol exerts antitumor effects on SCLC H446 cells and promotes H446 cell killing by cisplatin via modulation of intrinsic apoptosis.
Resveratrol increases the sensitivity of breast cancer MDA-MB-231 cell line to cisplatin by regulating intrinsic apoptosis
TLDR
RSV, an effective anti-oxidant, and CDDP as an effective drug in cancer treatment, were found to increase apoptosis when given in the MDA-MB-231 cell.
Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition
TLDR
The studies suggest resveratrol may sensitize human hepatoma cells to cisplatin chemotherapy via glutamine metabolism inhibition, and over-expression of ASCT2 can attenuate cisPlatin-induced ROS production, γH2AX foci formation and apoptosis in human hepatomas cells.
Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin.
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress-mediated apoptosis and G2/M phase arrest
TLDR
Resveratrol is a promising adjuvant for DDP during GC chemotherapy by inducing endoplasmic reticulum stress-mediated apoptosis and G2/M phase arrest via activation of the PERK/eIF2α/activating transcription factor 4 (ATF4)/CHOP signaling pathway and caspase-12 and by inactivating the CDK1-cyclin B1 complex.
Molecular mechanisms of natural compounds in cell death induction and sensitization to chemotherapeutic drugs in lung cancer
TLDR
This review highlights representative plant‐derived compounds with cancer chemopreventive and sensitizing effects in combination with chemotherapeutic drugs with various cell death‐inducing mechanisms and provides a reference and new perspective for application of phytochemical agents as potential anti‐lung cancer drugs for further cancer drug research and development.
Pterostilbene exerts anti-cancer activity via endoplasmic reticulum stress activation in human lung adenocarcinoma cells
TLDR
Investigation of anticancer activity of Pte against human lung adenocarcinoma cells in vitro and the role of endoplasmic reticulum stress (ERS) is explored to suggest that the activation of ERS signaling may represent a novel therapeutic intervention for lungAdenocARCinoma.
Anticancer Molecular Mechanisms of Resveratrol
TLDR
Promising role to counteract multidrug resistance: in adjuvant therapy, associated with 5-fluoruracyl and cisplatin, resveratrol had additive and/or synergistic effects increasing the chemosensitization of cancer cells.
Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2
TLDR
Resveratrol inhibits A549 cells proliferation by inhibiting COX-2 expression and it was closely related with clinical stages in lung adenocarcinoma tissues.
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