Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression.

@article{Tessitore2000ResveratrolDT,
  title={Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression.},
  author={Luciana Tessitore and Annalisa Davit and Ivana Sarotto and Giovanna Caderni},
  journal={Carcinogenesis},
  year={2000},
  volume={21 8},
  pages={1619-22}
}
We investigated whether resveratrol (RV) affects azoxymethane (AOM)-induced colon carcinogenesis, by administering RV (200 microg/kg/day in drinking water) to male F344 rats for 100 days, beginning 10 days before carcinogen treatment (two weekly doses of 15 mg/kg AOM). Aberrant crypt foci (ACF) were isolated and proliferation, apoptosis and expression of the cell cycle genes bax and p21 were determined. RV significantly reduced the number of ACF/colon [25.7 +/- 3.6 (mean +/- SEM) versus 39.4… CONTINUE READING

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