Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells.

@article{Zhou2009ResveratrolAT,
  title={Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells.},
  author={Haibin Zhou and Linshan Shang and Xia Li and Xiyu Zhang and Guimin Gao and Chenhong Guo and Bingxi Chen and Qiji Liu and Yaoqin Gong and Changshun Shao},
  journal={Experimental cell research},
  year={2009},
  volume={315 17},
  pages={2953-62}
}
Resveratrol has been shown to possess many health-benefiting effects, including the promotion of bone formation. In this report we investigated the mechanism by which resveratrol promotes osteoblastic differentiation from pluripotent mesenchymal cells. Since Wnt signaling is well documented to induce osteoblastogenesis and bone formation, we characterized the factors involved in Wnt signaling in response to resveratrol treatment. Resveratrol treatment of mesenchymal cells led to an increase in… CONTINUE READING
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