Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2.

@article{Li2012ResveratrolAB,
  title={Resveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2.},
  author={Zhen Li and Liang Wei Pang and Fang Fang and Gongliang Zhang and Jin Zhang and Min Xie and Liecheng Wang},
  journal={Brain research},
  year={2012},
  volume={1450},
  pages={116-24}
}
A number of studies have demonstrated that resveratrol (Res), a natural polyphenol compound found in plants, shows potent neuroprotective, anti-inflammatory and antioxidant effects; however, its ability to prevent ischemia-induced brain damage remains unclear. Here we tested whether Res played a neuroprotective role in a rat brain ischemia model induced by middle cerebral artery occlusion (MCAO). Adult male rats were randomly assigned into four experimental groups: sham operation (sham… CONTINUE READING