Resveratrol attenuates MPP+-induced mitochondrial dysfunction and cell apoptosis via AKT/GSK-3β pathway in SN4741 cells.

@article{Zeng2017ResveratrolAM,
  title={Resveratrol attenuates MPP+-induced mitochondrial dysfunction and cell apoptosis via AKT/GSK-3β pathway in SN4741 cells.},
  author={Weijun Zeng and Wei Zhang and Fangfang Lu and Li Gao and Guodong Gao},
  journal={Neuroscience letters},
  year={2017},
  volume={637},
  pages={50-56}
}
Oxidative stress and mitochondrial dysfunction play crucial role in the dopaminergic neurons death, which is the pathological feature of Parkinson's disease (PD). Resveratrol (Res), a polyphenol derived from grapes and blueberries, has been reported to reduce oxidative stress injury and to restore mitochondrial function. In this study, we aimed to explore the underlying molecular mechanism of the beneficial effects of Res against MPP+- induced mitochondrial dysfunction and cell apoptosis in… CONTINUE READING

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References

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Showing 1-10 of 32 references

Glycogen synthase kinase - 3 beta ( GSK 3 beta ) binds to and promotes the actions of p 53

  • G. N. Bijur Watcharasit, L. Song, J. Zhu, X. Chen, R. S. Jope
  • Neurobiol . Dis .
  • 2016

The role of dietary polyphenols in tumor necrosis factor - related apoptosis inducing ligand ( TRAIL ) - induced apoptosis for cancer chemoprevention

  • W. Krol Szliszka
  • Nat . Protoc .
  • 2012

GSK - 3 in neurodegenerative diseases

  • F. Luo, L. Wei, Z. Liu, P. Xu
  • Int J Alzheimers Dis
  • 2011

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