Resveratrol and rapamycin: are they anti‐aging drugs?
@article{Kaeberlein2010ResveratrolAR, title={Resveratrol and rapamycin: are they anti‐aging drugs?}, author={M. Kaeberlein}, journal={BioEssays}, year={2010}, volume={32} }
Studies of the basic biology of aging have advanced to the point where anti‐aging interventions, identified from experiments in model organisms, are beginning to be tested in people. Resveratrol and rapamycin, two compounds that target conserved longevity pathways and may mimic some aspects of dietary restriction, represent the first such interventions. Both compounds have been reported to slow aging in yeast and invertebrate species, and rapamycin has also recently been found to increase life… CONTINUE READING
Topics from this paper
Paper Mentions
87 Citations
Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner
- Biology, Medicine
- Aging
- 2013
- 22
- PDF
The role of autophagy in the regulation of yeast life span
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 2018
- 18
Resveratrol in cardiovascular health and disease
- Biology, Medicine
- Annals of the New York Academy of Sciences
- 2011
- 208
Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues
- Medicine
- Oncotarget
- 2015
- 4
- PDF
Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans
- Biology, Medicine
- Longevity & healthspan
- 2012
- 43
- PDF
References
SHOWING 1-10 OF 34 REFERENCES
Resveratrol in prevention and treatment of common clinical conditions of aging
- Medicine
- Clinical interventions in aging
- 2008
- 170
- PDF
The Sirtuin family: therapeutic targets to treat diseases of aging.
- Biology, Medicine
- Current opinion in chemical biology
- 2008
- 242
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
- Biology, Medicine
- Cell metabolism
- 2008
- 1,033
- PDF
Substrate-specific Activation of Sirtuins by Resveratrol*
- Biology, Medicine
- Journal of Biological Chemistry
- 2005
- 701
- PDF
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
- Biology, Medicine
- Nature
- 2007
- 1,440
- PDF
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
- Biology, Medicine
- PloS one
- 2008
- 572
- PDF
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- Biology, Medicine
- Nature
- 2009
- 2,669
- Highly Influential
- PDF