Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells

  title={Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells},
  author={Lauren L{\'u}cia Zamin and Eduardo Filippi-Chiela and Patr{\'i}cia Dillenburg-Pilla and Fabiana Horn and Christianne Gazzana Salbego and Guido Lenz},
  journal={Cancer Science},
Glioma is the most frequent and malignant primary human brain tumor with dismal prognosis despite multimodal therapy. Resveratrol and quercetin, two structurally related and naturally occurring polyphenols, are proposed to have anticancer effects. We report here that resveratrol and quercetin decreased the cell number in four glioma cell lines but not in rat astrocytes. Low doses of resveratrol (10 µM) or quercetin (25 µM) separately had no effect on apoptosis induction, but had a strong effect… 
Quercetin derivative induces cell death in glioma cells by modulating NF-κB nuclear translocation and caspase-3 activation.
  • C. J. Kiekow, F. Figueiró, G. Gosmann
  • Biology
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2016
Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.
Data support a positive role of HDAC inhibition on the senescence induced by Resveratrol and quercetin, and therefore co-treatment ofHDAC inhibitors and polyphenols emerges as a potential alternative for gliomas.
Quercetin Increases the Efficacy of Glioblastoma Treatment Compared to Standard Chemoradiotherapy by the Suppression of PI-3-Kinase-Akt Pathway
The data indicate that the supplementation of standard therapy with quercetin increases efficacy of treatment of experimental glioblastoma through synergism in the induction of apoptosis via the cleavage of caspase-3 and PARP-1 and by the suppression of the actitivation of Akt pathway.
Quercetin Inhibits Proliferation and Drug Resistance in KB/VCR Oral Cancer Cells and Enhances Its Sensitivity to Vincristine
Evidence is provided that quercetin induced apoptosis and reversed drug resistance in oral tumor cells and may be a potential candidate for other tumors treatment.
Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown
This study suggests that XIAP inhibitors may sensitize gliomas to certain drugs and induce death and that the mechanisms of sensitization involve apoptosis, senescence and p53 signaling.
Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals.
The rejuvenating effects of T3s and QUE on pre- senescent and senescent primary cells might be the net results of a senolytic activity on senescent cells and a selective survival of a sub-population of non-senescent cells in the culture.
Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells
The presence of Rsv forces cells treated with TMZ through mitosis leading to mitotic catastrophe and senescence, reducing the clonogenic capacity of glioma cells and increasing the chronic effects of temozolomide.


Antiproliferative effect of quercetin in the human U138MG glioma cell line
It is suggested that quercetin induced growth inhibition and cell death in the U138MG human glioma cell line, while exerting a cytoprotective effect in normal cell cultures.
Underlying Mechanism of Quercetin-induced Cell Death in Human Glioma Cells
Findings suggest that quercetin results in human glioma cell death through caspase-dependent mechanisms involving down-regulation of ERK, Akt, and survivin.
Resveratrol-induced apoptotic death in human U251 glioma cells
The results suggest that multiple signaling pathways may underlie the apoptotic death of U251 glioma induced by resveratrol, which warrants further exploration as an anticancer agent in human gliomas.
Resveratrol Suppresses the Angiogenesis and Tumor Growth of Gliomas in Rats
Resveratrol caused significant glioma cell cytotoxicity and apoptosis, exerted antitumor effects on the s.c. and intracerebral gliomas, and inhibited angiogenesis in s.C.gliomas.
The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts
Findings suggest that quercetin induces apoptosis through a mitochondria-dependent mechanism involving ERK activation and inhibits migration through activation of ERK and p38 pathways and may exert both protective and deleterious effects in bone repair.
Quercetin inhibits p21‐RAS expression in human colon cancer cell lines and in primary colorectal tumors
Immunocytochemical studies have revealed that 10 μM quercetin reduced the steady state levels of p21‐ras proteins in both colon cancer cell lines and primary colorectal tumors. These findings were
Stabilization of p53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG2 Cells
The data demonstrate that quercetin stabilized p53 at both the mRNA and protein levels to reactivate p53-dependent cell cycle arrest and apoptosis in HepG2 cells.
Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468.
The observation that quercetin strongly inhibited, in a time- and dose-dependent fashion, the expression of the mutated p53 protein, which is the only form present at high levels in this cell line, suggests that this inhibition takes place at the translational level.