Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells

@article{Zamin2009ResveratrolAQ,
  title={Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells},
  author={Lauren L{\'u}cia Zamin and Eduardo Filippi-Chiela and Patr{\'i}cia Dillenburg-Pilla and Fabiana Horn and Christianne Gazzana Salbego and Guido Lenz},
  journal={Cancer Science},
  year={2009},
  volume={100}
}
Glioma is the most frequent and malignant primary human brain tumor with dismal prognosis despite multimodal therapy. Resveratrol and quercetin, two structurally related and naturally occurring polyphenols, are proposed to have anticancer effects. We report here that resveratrol and quercetin decreased the cell number in four glioma cell lines but not in rat astrocytes. Low doses of resveratrol (10 µM) or quercetin (25 µM) separately had no effect on apoptosis induction, but had a strong effect… 
Quercetin derivative induces cell death in glioma cells by modulating NF-κB nuclear translocation and caspase-3 activation.
  • C. J. Kiekow, F. Figueiró, G. Gosmann
  • Biology
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2016
Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.
TLDR
Data support a positive role of HDAC inhibition on the senescence induced by Resveratrol and quercetin, and therefore co-treatment ofHDAC inhibitors and polyphenols emerges as a potential alternative for gliomas.
Quercetin Increases the Efficacy of Glioblastoma Treatment Compared to Standard Chemoradiotherapy by the Suppression of PI-3-Kinase-Akt Pathway
TLDR
The data indicate that the supplementation of standard therapy with quercetin increases efficacy of treatment of experimental glioblastoma through synergism in the induction of apoptosis via the cleavage of caspase-3 and PARP-1 and by the suppression of the actitivation of Akt pathway.
Quercetin Inhibits Proliferation and Drug Resistance in KB/VCR Oral Cancer Cells and Enhances Its Sensitivity to Vincristine
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Evidence is provided that quercetin induced apoptosis and reversed drug resistance in oral tumor cells and may be a potential candidate for other tumors treatment.
Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown
TLDR
This study suggests that XIAP inhibitors may sensitize gliomas to certain drugs and induce death and that the mechanisms of sensitization involve apoptosis, senescence and p53 signaling.
Pleiotropic Effects of Tocotrienols and Quercetin on Cellular Senescence: Introducing the Perspective of Senolytic Effects of Phytochemicals.
TLDR
The rejuvenating effects of T3s and QUE on pre- senescent and senescent primary cells might be the net results of a senolytic activity on senescent cells and a selective survival of a sub-population of non-senescent cells in the culture.
Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells
TLDR
The presence of Rsv forces cells treated with TMZ through mitosis leading to mitotic catastrophe and senescence, reducing the clonogenic capacity of glioma cells and increasing the chronic effects of temozolomide.
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