Resveratrol and life extension

@article{Agarwal2011ResveratrolAL,
  title={Resveratrol and life extension},
  author={Beamon Agarwal and Joseph A. Baur},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1215}
}
  • B. Agarwal, J. Baur
  • Published 2011
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Age is the most important risk factor for diseases affecting the Western world, and slowing age‐related degeneration would greatly improve the quality of human life. In rodents, caloric restriction (CR) extends lifespan by up to 50%. However, attempts to mimic the effects of CR pharmacologically have been limited by our poor understanding of the mechanisms involved. SIRT1 is proposed to mediate key aspects of CR, and small molecule activators may therefore act as CR mimetics. The polyphenol… Expand
Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8
TLDR
It is found that long-term dietary resveratrol activates AMPK pathways and pro-survival routes such as SIRT1 in vivo and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation. Expand
Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases
TLDR
Pros and cons on RSV analogues and sirtuin 1 activators tested in preclinical and clinical trials to hamper neurological deficit, cardiovascular complications, diabetes, bone and muscle deterioration, and cancer are discussed. Expand
Resveratrol: A Sirtuin Activator and The Fountain of Youth
TLDR
The purpose of aging research is the identification of interventions that may avoid or ameliorate the ravages of time, where improved longevity is coupled to a corresponding healthspan extension. Expand
Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity.
TLDR
Calorie restriction with adequate nutrition is the only non-genetic, and the most consistent non-pharmacological intervention that extends lifespan in model organisms from yeast to mammals, and protects against the deterioration of biological functions, delaying or reducing the risk of many age-related diseases. Expand
Are sirtuins viable targets for improving healthspan and lifespan?
TLDR
The current status and controversies surrounding the potential of sirtuins as novel pharmacological targets are covered, with a focus on SIRT1. Expand
Chapter 5 Where and How in the mTOR Pathway Inhibitors Fight Aging : Rapamycin , Resveratrol , and Metformin Sage Arbor
The molecular mechanisms underlying the quality and quantity of life extension appear to sometimes be orthogonal. For example, while resveratrol has continued to prove beneficial in reducing obesity,Expand
Where and How in the mTOR Pathway Inhibitors Fight Aging: Rapamycin, Resveratrol, and Metformin
  • Sage Arbor
  • Biology
  • Resveratrol - Adding Life to Years, Not Adding Years to Life
  • 2019
TLDR
Comparisons between rapamycin, resveratrol, and metformin targets, downstream pathway effects, dosage, and clinical trials will be discussed and CR mimics are currently being investigated to elucidate the best dosage, route of administration, timing in life, where best to inhibit in the mTOR pathway, and effects of long-term use on mTORC1 verse m TORC2 complexes. Expand
Diet and Aging
Nutrition has important long-term consequences for health that are not only limited to the individual but can be passed on to the next generation. It can contribute to the development and progressionExpand
Diet and Aging
  • S. Ribaric
  • Biology, Medicine
  • Oxidative medicine and cellular longevity
  • 2012
TLDR
At present, the most promising alternatives to the use of CR in humans seem to be exercise, alone or in combination with reduced calorie intake, and theUse of plant-derived polyphenol resveratrol as a food supplement. Expand
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
TLDR
Mice treated with a moderate dose of resveratrol showed increased mitochondrial biogenesis and function, AMPK activation, and increased NAD(+) levels in skeletal muscle, whereas SIRT1 knockouts displayed none of these benefits, whereas a mouse overexpressing Sirt1 mimicked these effects. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 71 REFERENCES
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
TLDR
It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife. Expand
Resveratrol improves health and survival of mice on a high-calorie diet
TLDR
It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing. Expand
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
TLDR
Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR, andGene expression profiling suggests that both CR and resver atrol may retard some aspect of aging through alterations in chromatin structure and transcription. Expand
Sirt1 protects against high-fat diet-induced metabolic damage
TLDR
Data is presented indicating that beneficial effects of Sirt1 are due to at least two mechanisms: induction of antioxidant proteins MnSOD and Nrf1, possibly via stimulation of PGC1α, and lower activation of proinflammatory cytokines, such as TNFα and IL-6, via down-modulation of NFκB activity. Expand
Calorie restriction mimetics: an emerging research field
TLDR
New research has focused on the development of ‘CR mimetics’, which is to identify compounds that mimic CR effects by targeting metabolic and stress response pathways affected by CR, but without actually restricting caloric intake. Expand
SirT1 gain of function increases energy efficiency and prevents diabetes in mice.
TLDR
SirT1 gain of function primes the organism for metabolic adaptation to insulin resistance, increasing hepatic insulin sensitivity and decreasing whole-body energy requirements, which have important implications for Sirtuin-based therapies in humans. Expand
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
TLDR
The present findings support the notion that enhanced sensitivity to insulin plays a prominent role in the actions of CR and GH resistance on longevity and imply that somatotropic signaling is critically important not only in the control of aging and longevity under conditions of unlimited food supply but also in mediating the effects of CR on life span. Expand
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.
TLDR
The metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 that is devoid of direct action on AMPK that robustly enhances endurance running performance and strongly protects from diet-induced obesity and insulin resistance by enhancing oxidative metabolism in skeletal muscle, liver, and brown adipose tissue is reported. Expand
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
TLDR
RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity. Expand
Substrate-specific Activation of Sirtuins by Resveratrol*
TLDR
It is shown here that resveratrol is a substrate-specific activator of yeast Sir2 and human SirT1 and that in three different yeast strain backgrounds, resver atrol has no detectable effect on Sir2 activity in vivo, as measured by rDNA recombination, transcriptional silencing near telomeres, and life span. Expand
...
1
2
3
4
5
...