Resveratrol and life extension

@article{Agarwal2011ResveratrolAL,
  title={Resveratrol and life extension},
  author={Beamon Agarwal and Joseph A. Baur},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1215}
}
  • B. Agarwal, J. Baur
  • Published 1 January 2011
  • Biology
  • Annals of the New York Academy of Sciences
Age is the most important risk factor for diseases affecting the Western world, and slowing age‐related degeneration would greatly improve the quality of human life. In rodents, caloric restriction (CR) extends lifespan by up to 50%. However, attempts to mimic the effects of CR pharmacologically have been limited by our poor understanding of the mechanisms involved. SIRT1 is proposed to mediate key aspects of CR, and small molecule activators may therefore act as CR mimetics. The polyphenol… 

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

TLDR
It is found that long-term dietary resveratrol activates AMPK pathways and pro-survival routes such as SIRT1 in vivo and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation.

Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases

TLDR
Pros and cons on RSV analogues and sirtuin 1 activators tested in preclinical and clinical trials to hamper neurological deficit, cardiovascular complications, bone and muscle and cancer are discussed.

Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity.

TLDR
Calorie restriction with adequate nutrition is the only non-genetic, and the most consistent non-pharmacological intervention that extends lifespan in model organisms from yeast to mammals, and protects against the deterioration of biological functions, delaying or reducing the risk of many age-related diseases.

Resveratrol: A Sirtuin Activator and The Fountain of Youth

TLDR
The purpose of aging research is the identification of interventions that may avoid or ameliorate the ravages of time, where improved longevity is coupled to a corresponding healthspan extension.

Are sirtuins viable targets for improving healthspan and lifespan?

TLDR
The current status and controversies surrounding the potential of sirtuins as novel pharmacological targets are covered, with a focus on SIRT1.

Chapter 5 Where and How in the mTOR Pathway Inhibitors Fight Aging : Rapamycin , Resveratrol , and Metformin Sage Arbor

TLDR
Comparisons between rapamycin, resveratrol, and metformin targets, downstream pathway effects, dosage, and clinical trials will be discussed and CR mimics are currently being investigated to elucidate the best dosage, route of administration, timing in life, where best to inhibit in the mTOR pathway, and effects of long-term use on mTORC1 verse m TORC2 complexes.

Where and How in the mTOR Pathway Inhibitors Fight Aging: Rapamycin, Resveratrol, and Metformin

  • Sage Arbor
  • Biology
    Resveratrol - Adding Life to Years, Not Adding Years to Life
  • 2019
TLDR
Comparisons between rapamycin, resveratrol, and metformin targets, downstream pathway effects, dosage, and clinical trials will be discussed and CR mimics are currently being investigated to elucidate the best dosage, route of administration, timing in life, where best to inhibit in the mTOR pathway, and effects of long-term use on mTORC1 verse m TORC2 complexes.

Diet and Aging

  • S. Ribaric
  • Biology
    Oxidative medicine and cellular longevity
  • 2012
TLDR
At present, the most promising alternatives to the use of CR in humans seem to be exercise, alone or in combination with reduced calorie intake, and theUse of plant-derived polyphenol resveratrol as a food supplement.

Sirtuin Activation by Small Molecules

TLDR
Recent progress, controversies and challenges surrounding small molecule activators of sirtuins making SIRT1 an attractive target for therapeutic interventions for a variety of age related diseases are addressed.
...

References

SHOWING 1-10 OF 66 REFERENCES

Resveratrol improves health and survival of mice on a high-calorie diet

TLDR
It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.

Sirt1 protects against high-fat diet-induced metabolic damage

TLDR
Data is presented indicating that beneficial effects of Sirt1 are due to at least two mechanisms: induction of antioxidant proteins MnSOD and Nrf1, possibly via stimulation of PGC1α, and lower activation of proinflammatory cytokines, such as TNFα and IL-6, via down-modulation of NFκB activity.

Calorie restriction mimetics: an emerging research field

TLDR
New research has focused on the development of ‘CR mimetics’, which is to identify compounds that mimic CR effects by targeting metabolic and stress response pathways affected by CR, but without actually restricting caloric intake.

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

TLDR
The present findings support the notion that enhanced sensitivity to insulin plays a prominent role in the actions of CR and GH resistance on longevity and imply that somatotropic signaling is critically important not only in the control of aging and longevity under conditions of unlimited food supply but also in mediating the effects of CR on life span.

Substrate-specific Activation of Sirtuins by Resveratrol*

TLDR
It is shown here that resveratrol is a substrate-specific activator of yeast Sir2 and human SirT1 and that in three different yeast strain backgrounds, resver atrol has no detectable effect on Sir2 activity in vivo, as measured by rDNA recombination, transcriptional silencing near telomeres, and life span.

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

TLDR
SirT1 does not behave like a classical tumor-suppressor gene but the antitumor activity of resveratrol is mediated at least in part by SirT1, suggesting that part of the protection afforded by resver atrol requires the SirT 1-encoded protein.
...