Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a

@article{DelFolloMartnez2013ResveratrolAQ,
  title={Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a},
  author={Armando Del Follo-Mart{\'i}nez and Nivedita Banerjee and Xiangrong Li and Stephen H. Safe and Susanne U Mertens-Talcott},
  journal={Nutrition and Cancer},
  year={2013},
  volume={65},
  pages={494 - 504}
}
Resveratrol and quercetin (RQ) in combination (1:1 ratio) previously inhibited growth in human leukemia cells. This study investigated the anticancer activity of the same mixture in HT-29 colon cancer cells. RQ decreased the generation of reactive oxygen species (ROS) by up to 2.25-fold and increased the antioxidant capacity by up to 3-fold in HT-29 cells (3.8–60 μg/mL), whereas IC50 values for viability were 18.13, 18.73, and 11.85 μg/mL, respectively. RQ also induced caspase-3-cleavage (2… 
Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells
TLDR
It is demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating miR-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down- Regulating the expression of EGFR.
Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway
TLDR
Quercetin inhibits the proliferation and induces apoptosis of NSCLC cells by mediating signaling via the lncRNA SNHG7/miR-34a-5p pathway.
Antiproliferative effect of quercetin in mammary and epidermoid cancer cells
TLDR
Investigation of the ability of quercetin to inhibit cell proliferation in two cancer cell lines with epithelial origin and A-431 epidermoid tumor cells suggested that first outcome of quERCetin in displaying antiproliferative properties was associated with the cytostatic effect rather than the cytotoxic activity.
Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer
TLDR
It is demonstrated that Qu evoked ER stress to involve in mitochondria apoptosis pathway via the p-STAT3/Bcl-2 axis in OC cell lines and in primary OC cells, revealing a novel role of ER stress as a “double edge sword” participating in Qu-induced apoptosis of OC.
Pro-Apoptotic Activities of Polyphenolics From Açai (Euterpe oleracea Martius) in Human SW-480 Colon Cancer Cells
TLDR
Results strongly suggest that açai polyphenolic extract has antiinflammatory and cytotoxic activities in colon cancer cells and can be effective as natural colon cancer chemopreventive agents.
Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells
TLDR
Overall results of the current study suggested that QUE improves the synergistic anticancer efficacy in combination with PI-103, ROT, and G0 6983 in MCF-7 and RAW 264.7 cells.
Quercetin Enhances the Suppressive Effects of Doxorubicin on the Migration of MDA-MB-231 Breast Cancer Cell Line
TLDR
Que inhibits the viability and migration of MDA-MB-231 breast cancer cells and synergistically enhances the effects of dox on the survival and Migration of these cells.
Apigenin inhibits in vitro and in vivo tumorigenesis in cisplatin-resistant colon cancer cells by inducing autophagy, programmed cell death and targeting m-TOR/PI3K/Akt signalling pathway.
TLDR
The results indicate that Apigenin could inhibit the growth of cisplatin-resistant colon cancer cells in vitro and in vivo and may be used for the improvement of therapy of colon cancer.
ANTICANCER EFFECTS OF GRAPE SEED EXTRACT ON HUMAN CANCER: A REVIEW
TLDR
GSE-related anti-cancer activity mostly relies on the induced increase in reactive oxygen species, followed by the orchestrated downand up-regulation of several key-molecular pathways, including MAPK kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
Curcumin decreases specificity protein expression in bladder cancer cells.
TLDR
Results show for the first time that one of the underlying mechanisms of action of curcumin as a cancer chemotherapeutic agent is due, in part, to decreased expression of Sp transcription factors in bladder cancer cells.
Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells.
TLDR
Evidence is provided demonstrating the antitumor effect of trans-resveratrol via a ROS-dependent apoptosis pathway in colorectal carcinoma through the production of superoxide anions in the mitochondria of cells undergoing apoptosis.
Regulation of Survivin and Bcl‐2 in HepG2 Cell Apoptosis Induced by Quercetin
TLDR
It is reported that quercetin can inhibit proliferation and induce apoptosis in HepG2 cells in dose‐ and time‐dependent manner and the expression of survivin may be associated with Bcl‐2 expression, and the inhibition expression of Survivin, in conjunction with BCl‐2, might cause more pronounced apoptotic effects.
Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells.
Mechanisms of grape seed procyanidin-induced apoptosis in colorectal carcinoma cells.
TLDR
GSP inhibited the proliferation of some colorectal carcinoma cell lines and was associated with an apoptotic mechanism involving a loss of mitochondrial membrane potential and caspase-3 activation in these cells.
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.
TLDR
Sulforaphane either alone or in combination with quercetin can eliminate cancer stem cell-characteristics, suggesting the blockade of signaling involved in early metastasis.
Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells.
...
...