Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis

  title={Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits
cancer invasion and metastasis},
  author={Monica Savio and Daniela Ferraro and Cristina Maccario and Rita Vaccarone and Lasse D Jensen and Federica Corana and Barbara Mannucci and L{\'i}via Carla de Souza Nassar Bianchi and Yihai Cao and Lucia Anna Stivala},
  booktitle={Scientific reports},
We investigated the preventive effects of resveratrol analogue 4,4'-dihydroxy-trans-stilbene (DHS) on cancer invasion and metastasis. Two different in vivo approaches of mouse and zebrafish lung cancer invasion models were employed in our study. The in vitro results showed that DHS displays potent inhibition on anchorage-dependent or -independent cell growth of LLC cells, leading to impairment of the cell cycle progression with reduction of cell numbers arresting at the G1 phase, an evident… CONTINUE READING
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