Resveratrol ameliorates high glucose-induced oxidative stress injury in human umbilical vein endothelial cells by activating AMPK.

@article{Zhou2015ResveratrolAH,
  title={Resveratrol ameliorates high glucose-induced oxidative stress injury in human umbilical vein endothelial cells by activating AMPK.},
  author={D. Zhou and Yong Su and Pan Gao and Qi-hong Yang and Zhe Wang and Qiang Xu},
  journal={Life sciences},
  year={2015},
  volume={136},
  pages={94-9}
}
AIMS To investigate the effects of resveratrol on high glucose (HG)-induced vascular injury, and to establish the mechanism(s) underlying these effects. MAIN METHODS Human umbilical vein endothelial cells (HUVECs) were treated with glucose, and then incubated with resveratrol in the presence or absence of Compound C, an AMP-activated protein kinase (AMPK) inhibitor. Cell viability was determined using the Cell Counting Kit-8 (CCK-8) method. Reactive oxygen species, malondialdehyde, and… CONTINUE READING
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