Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

@inproceedings{Park2012ResveratrolAA,
  title={Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases},
  author={Sung-Jun Park and Faiyaz Ahmad and Andrew Philp and Keith Baar and Tishan Williams and Haibin Luo and Hengming Ke and Holger Rehmann and Ronald Taussig and Alexandra L. Brown and Myung Kyoo Kim and Michael A. Beaven and Alex B. Burgin and Vincent C. Manganiello and Jay H. Chung},
  booktitle={Cell},
  year={2012}
}
Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels. The resulting activation of Epac1, a cAMP effector protein, increases intracellular Ca(2… CONTINUE READING

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