Resveratrol activates SIRT1 in a Lamin A-dependent manner.

  title={Resveratrol activates SIRT1 in a Lamin A-dependent manner.},
  author={Shrestha Ghosh and Baohua Liu and Zhongjun Zhou},
  journal={Cell cycle},
  volume={12 6},
Human sirtuin1 (SIRT1), the closest homolog of the yeast sir2 protein, functions as an NAD+-dependent histone and non-histone protein deacetylase in several cellular processes, like energy metabolism, stress responses, aging, etc. In our recent study, we have shown that lamin A (a major nuclear matrix protein) directly binds with and activates SIRT1. Resveratrol, a natural phenol, has long been known as an activator of SIRT1. However, resveratrol's direct activation of SIRT1 has been refuted… CONTINUE READING
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