Resveratrol Stimulates Sphingosine-1-Phosphate Signaling of Cathelicidin Production

@inproceedings{Park2013ResveratrolSS,
  title={Resveratrol Stimulates Sphingosine-1-Phosphate Signaling of Cathelicidin Production},
  author={Kyungho Park and Peter M Elias and Melanie Hupe and Andrew W. Borkowski and Richard L Gallo and Kyong-Oh Shin and Y Lee and Walter M. Holleran and Yoshikazu Uchida},
  booktitle={The Journal of investigative dermatology},
  year={2013}
}
We recently discovered a regulatory mechanism that stimulates the production of the multifunctional antimicrobial peptide cathelicidin antimicrobial peptide (CAMP). In response to subtoxic levels of ER stress, increased sphingosine-1-phosphate (S1P) production activates an NFκBC/EBPα-dependent pathway that enhances CAMP production in cultured human keratinocytes. As the multifunctional stilbenoid compound resveratrol (RESV) increases ceramide (Cer) levels, a precursor of S1P, we hypothesized… CONTINUE READING
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