Resveratrol Sensitizes Tamoxifen in Antiestrogen-Resistant Breast Cancer Cells with Epithelial-Mesenchymal Transition Features

@article{Shi2013ResveratrolST,
  title={Resveratrol Sensitizes Tamoxifen in Antiestrogen-Resistant Breast Cancer Cells with Epithelial-Mesenchymal Transition Features},
  author={Xiao-Peng Shi and S. Miao and Yin Wu and W. Zhang and Xiao-Fang Zhang and Huanhuan Ma and Hai-Li Xin and J. Feng and A. Wen and Y. Li},
  journal={International Journal of Molecular Sciences},
  year={2013},
  volume={14},
  pages={15655 - 15668}
}
Tamoxifen resistance remains to be a huge obstacle in the treatment of hormone-dependent breast cancer, and this therefore highlights the dire need to explore the underlying mechanisms. The epithelial-mesenchymal transition (EMT) is a molecular process through which an epithelial cell transfers into a mesenchymal phenotype. Roles of EMT in embryo development, cancer invasion and metastasis have been extensively reported. Herein, we established tamoxifen-resistant MCF-7/TR breast cancer cells… Expand
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