Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

  title={Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate},
  author={D. R. Valenzano and E. Terzibasi and Tyrone Genade and Antonino Cattaneo and L. Domenici and A. Cellerino},
  journal={Current Biology},
  • D. R. Valenzano, E. Terzibasi, +3 authors A. Cellerino
  • Published 2006
  • Medicine, Biology
  • Current Biology
  • Resveratrol, a natural phytoalexin found in grapes and red wine, increases longevity in the short-lived invertebrates Caenorhabditis elegans and Drosophila and exerts a variety of biological effects in vertebrates, including protection from ischemia and neurotoxicity. Its effects on vertebrate lifespan were not yet known. The relatively long lifespan of mice, which live at least 2.5 years, is a hurdle for life-long pharmacological trials. Here, the authors used the short-lived seasonal fish… CONTINUE READING
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