Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

@article{Corpas2018ResveratrolIB,
  title={Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement},
  author={Rub{\'e}n Corpas and Christian Gri{\~n}{\'a}n-Ferr{\'e} and Eduard Rodrı́guez-Farr{\'e} and Merc{\'e} Pall{\`a}s and Coral Sanfeliu},
  journal={Molecular Neurobiology},
  year={2018},
  volume={56},
  pages={1502-1516}
}
Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xTg-AD) mice to discern the mechanisms involved in a potential inducement of resilience against age-related neurodegeneration and Alzheimer’s disease (AD). Mice were fed with a diet… Expand
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