Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways

@inproceedings{Cheng2018ResveratrolInducedDO,
  title={Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways},
  author={Liang Cheng and Bin Yan and Ke Chen and Zhengdong Jiang and Cancan Zhou and Junyu Cao and Weikun Qian and Jie Li and Liankang Sun and Jiguang Ma and Qingyong Ma and Huanchen Sha},
  booktitle={Oxidative medicine and cellular longevity},
  year={2018}
}
NAF-1 (nutrient-deprivation autophagy factor-1), which is an outer mitochondrial membrane protein, is known to play important roles in calcium metabolism, antiapoptosis, and antiautophagy. Resveratrol, a natural polyphenolic compound, is considered as a potent anticancer agent. Nevertheless, the molecular mechanisms underlying the effects of resveratrol and NAF-1 and their mediation of drug resistance in pancreatic cancer remain unclear. Here, we demonstrate that resveratrol suppresses the… CONTINUE READING

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