Resuscitation with hypertonic saline dextran improves cardiac function in vivo and ex vivo after burn injury in sheep.

@article{Elgjo1998ResuscitationWH,
  title={Resuscitation with hypertonic saline dextran improves cardiac function in vivo and ex vivo after burn injury in sheep.},
  author={Geir Ivar Elgjo and Babu P Mathew and L F Poli de Figueriedo and Paul Joseph Schenarts and J. Wright Horton and Michael A. Dubick and George C. Kramer},
  journal={Shock},
  year={1998},
  volume={9 5},
  pages={375-83}
}
In a 24 h, double-blind, prospective trial, we tested the hypothesis that two 4 mL/kg doses of hypertonic saline dextran (HSD; 7.5% NaCl/6% dextran 70) given in addition to isotonic fluid treatment would produce both immediate and sustained benefit for the heart after large burn injury. 12 instrumented sheep were subjected to a 40% total body surface area full-thickness flame burn under halothane anesthesia. 1 h after burn, when the animals had recovered from anesthesia, the first dose of… CONTINUE READING