Resurrecting the role of transcription factor change in developmental evolution.

@article{Lynch2008ResurrectingTR,
  title={Resurrecting the role of transcription factor change in developmental evolution.},
  author={Vincent J. Lynch and G{\"u}nter P. Wagner},
  journal={Evolution; international journal of organic evolution},
  year={2008},
  volume={62 9},
  pages={2131-54}
}
A long-standing question in evolutionary and developmental biology concerns the relative contribution of cis-regulatory and protein changes to developmental evolution. Central to this argument is which mutations generate evolutionarily relevant phenotypic variation? A review of the growing body of evolutionary and developmental literature supports the notion that many developmentally relevant differences occur in the cis-regulatory regions of protein-coding genes, generally to the exclusion of… CONTINUE READING

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