Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

@article{Thornton2003ResurrectingTA,
  title={Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling},
  author={Joseph W. Thornton and Eleanor F. Need and David Crews},
  journal={Science},
  year={2003},
  volume={301},
  pages={1714 - 1717}
}
Receptors for sex and adrenal steroid hormones are absent from fully sequenced invertebrate genomes and have not been recovered from other invertebrates. Here we report the isolation of an estrogen receptor ortholog from the mollusk Aplysia californica and the reconstruction, synthesis, and experimental characterization of functional domains of the ancestral protein from which all extant steroid receptors (SRs) evolved. Our findings indicate that SRs are extremely ancient and widespread, having… Expand
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TLDR
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