Resurrecting Surviving Neandertal Lineages from Modern Human Genomes

  title={Resurrecting Surviving Neandertal Lineages from Modern Human Genomes},
  author={Benjamin Vernot and Joshua M. Akey},
Anatomically modern humans overlapped and mated with Neandertals such that non-African humans inherit ~1 to 3% of their genomes from Neandertal ancestors. We identified Neandertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 European and 286 East Asian individuals, recovering more than 15 gigabases of introgressed sequence that spans ~20% of the Neandertal genome (false discovery rate = 5%). Analyses of surviving archaic lineages suggest that there were… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 96 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 112 extracted citations


Publications referenced by this paper.
Showing 1-10 of 25 references

Higher levels of Neanderthal ancestry in East Asians than in Europeans

  • M. A. Yang, F. Jay, +6 authors M. Slatkin
  • Genetics
  • 2013

NHLBI Exome Sequencing Project , Analysis of 6 , 515 exomes reveals the recent origin of most human protein - coding variants

  • S. M. Leal, D. A. Nickerson, M. J. Bamshad, J. M. Akey
  • Nature
  • 2013

A highcoverage genome sequence from an archaic Denisovan individual

  • M. Kircher, M. T. Gansauge, +13 authors S. Pääbo
  • Science
  • 2012

ENCODE Project Consortium , An integrated encyclopedia of DNA elements in the human genome

  • M. Snyder
  • Nature
  • 2012

NHLBI Exome Sequencing Project , Evolution and functional impact of rare coding variation from deep sequencing of human exomes

  • J. M. Akey, GO Broad, GO Seattle
  • Science
  • 2012

Similar Papers

Loading similar papers…