Resurgence of pertussis calls for re-evaluation of pertussis animal models

@article{vanderArk2012ResurgenceOP,
  title={Resurgence of pertussis calls for re-evaluation of pertussis animal models},
  author={Arno A J van der Ark and Daniela Flavia Hozbor and Claire J. P. Boog and Bernard Metz and Germie P.J.M. van den Dobbelsteen and C{\'e}cile A. C. M. van Els},
  journal={Expert Review of Vaccines},
  year={2012},
  volume={11},
  pages={1121 - 1137}
}
Pertussis has recently re-emerged in well-vaccinated populations most likely due to a combination of pathogen adaptation and waning of vaccine-induced pertussis immunity. Changes in genomic content of the etiologic agent, Bordetella pertussis, observed in the postvaccination era can have a bearing on the efficacy of vaccines currently in use. Moreover, protective immune responses in vaccinees wane gradually depending on their originally induced size and breadth, and memory responses may not be… 
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References

SHOWING 1-10 OF 149 REFERENCES
Are vaccination programs and isolate polymorphism linked to pertussis re-emergence?
TLDR
The present review summarizes the current knowledge on B. pertussis variability in countries with different vaccination programs and discusses its potential impact on the recently observed increased incidence of whooping cough.
Long-term immunity against pertussis induced by a single nasal administration of live attenuated B. pertussis BPZE1.
TLDR
Evaluated long-term immunogenicity and protective efficacy induced by a single intranasal dose of BPZE1 showed significantly higher efficacy to protect adult and infant mice against B. pertussis infection than two administrations of an acellular pert Mussis vaccine (aPV).
A Live, Attenuated Bordetella pertussis Vaccine Provides Long-Term Protection against Virulent Challenge in a Murine Model
TLDR
It is suggested that BPZE1 is capable of conferring a high level of long-lived effective protection against virulent B. pertussis infection in antibody-deficient mice following passive transfer.
Dose Response of Attenuated Bordetella pertussis BPZE1-Induced Protection in Mice
TLDR
It is shown that after a single administration, BPZE1 induces dose-dependent protection against challenge with virulent B. pertussis in low-dose and in high-dose intranasal mouse lung colonization models.
Factors contributing to pertussis resurgence.
TLDR
Findings are summarized and factors contributing to pertussis resurgence in immunized populations are discussed, including antigenic divergence has been found between vaccine strains and clinical isolates in many countries with high vaccination coverage.
Nonhuman Primate Model of Pertussis
TLDR
The results demonstrate that the baboon provides an excellent model of clinical pertussis that will allow researchers to investigate pertussedis pathogenesis and disease progression, evaluate currently licensed vaccines, and develop improved vaccines and therapeutics.
A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in defining the mechanism of protective immunity.
TLDR
This model is used to define the protective mechanism of immunity against respiratory infection with B. pertussis and demonstrate a requirement for both specific T and B cells, and a comparison of estimated vaccine efficacy in children with potency in the murine model results in a highly significant correlation.
Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: implications for long-term immunity in children.
TLDR
The findings suggest that immunologic memory is more significant in protection than is the induction of immediate antibody responses and imply that vaccinated children still may be protected against disease following the disappearance of specific serum IgG.
Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen.
  • F. Mooi
  • Biology, Medicine
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2010
TLDR
It is proposed that the removal by vaccination of naïve infants as the major source for transmission was the crucial event which has driven the changes in B. pertussis populations, which has selected for strains which are more efficiently transmitted by primed hosts in which immunity has waned.
What is new in pertussis?
TLDR
With pertussis continuing to pose a serious threat to infants, and greatly affecting adolescents and adults, there remains a need to increase the awareness of physicians as to the growing pertussi problem, standardize diagnostic techniques, and implement various new vaccine strategies to enhance its control.
...
1
2
3
4
5
...