Resurgence of pertussis calls for re-evaluation of pertussis animal models

  title={Resurgence of pertussis calls for re-evaluation of pertussis animal models},
  author={Arno AJ van der Ark and D. Hozbor and C. Boog and B. Metz and Germie P.J.M. van den Dobbelsteen and C{\'e}cile A.C.M. van Els},
  journal={Expert Review of Vaccines},
  pages={1121 - 1137}
  • Arno AJ van der Ark, D. Hozbor, +3 authors Cécile A.C.M. van Els
  • Published 2012
  • Medicine
  • Expert Review of Vaccines
  • Pertussis has recently re-emerged in well-vaccinated populations most likely due to a combination of pathogen adaptation and waning of vaccine-induced pertussis immunity. Changes in genomic content of the etiologic agent, Bordetella pertussis, observed in the postvaccination era can have a bearing on the efficacy of vaccines currently in use. Moreover, protective immune responses in vaccinees wane gradually depending on their originally induced size and breadth, and memory responses may not be… CONTINUE READING

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