Resurgence of carbon monoxide: an endogenous gaseous vasorelaxing factor.

  title={Resurgence of carbon monoxide: an endogenous gaseous vasorelaxing factor.},
  author={Rui Wang},
  journal={Canadian journal of physiology and pharmacology},
  volume={76 1},
  • Rui Wang
  • Published 1998 in Canadian journal of physiology and pharmacology
Carbon monoxide (CO) is an endogenously generated gas that may play an important physiological role in the regulation of vascular tone. The CO-induced vasorelaxation, as a result of a direct action on vascular smooth muscles, has been demonstrated in many cases. Three major cellular mechanisms are proposed to explain the vasorelaxing effect of CO. These include the activation of soluble guanylyl cyclase, stimulation of various types of K channels, and inhibition of the cytochrome P450 dependent… CONTINUE READING