Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.

@article{Johnson2011ResurgenceIT,
  title={Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.},
  author={Trevor N. Johnson and Amin Rostami-Hodjegan},
  journal={Paediatric anaesthesia},
  year={2011},
  volume={21 3},
  pages={291-301}
}
AIMS AND OBJECTIVES (i) To describe an example of the development work required for building a 'pediatric physiologically based pharmacokinetic' (P-PBPK) model (Simcyp Pediatric ADME Simulator), (ii) to replicate pediatric clinical studies and undertake theoretical studies to show the potential applications of mechanistic PBPK in pediatric drug clinical investigation and practice, with emphasis on pediatric anesthesia. BACKGROUND PBPK models draw together the physiological and biochemical… CONTINUE READING

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