Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro.

Abstract

OBJECTIVE We are attempting to genetically-modify chondrocytes transplanted to cartilage in vitro as a prelude to gene therapy trials in patients with osteoarthritis. DESIGN With human cartilage and chondrocytes, we have explored the duration of binding of chondrocytes to cartilage in vitro and the expression of the beta-galactosidase gene introduced into… (More)

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