Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency.

@article{Atkins2007ResultsOT,
  title={Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency.},
  author={C. Atkins and B. Keene and W. Brown and J. R. Coats and M. Crawford and T. DeFrancesco and N. Edwards and P. Fox and L. Lehmkuhl and Michael Luethy and K. Meurs and Jean-Paul Petrie and F. Pipers and S. Rosenthal and J. Sidley and J. Straus},
  journal={Journal of the American Veterinary Medical Association},
  year={2007},
  volume={231 7},
  pages={
          1061-9
        }
}
  • C. Atkins, B. Keene, +13 authors J. Straus
  • Published 2007
  • Medicine
  • Journal of the American Veterinary Medical Association
  • OBJECTIVE To determine the efficacy of long-term enalapril administration in delaying the onset of congestive heart failure (CHF). DESIGN Placebo-controlled, double-blind, multicenter, randomized trial. ANIMALS 124 dogs with compensated mitral valve regurgitation (MR). PROCEDURES Dogs randomly assigned to receive enalapril or placebo were monitored for the primary endpoint of onset of CHF for < or = 58 months. Secondary endpoints included time from study entry to the combined endpoint of… CONTINUE READING

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