Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial.

  title={Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial.},
  author={Chelsea S. Kidwell and Kennedy R. Lees and Keith Muir and Christopher Chen and Stephen M Davis and Deidre Anne De Silva and Christopher J Weir and Jeffrey Gornbein and Jeffry R. Alger and Jeffrey L. Saver},
  volume={40 5},
BACKGROUND AND PURPOSE Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients. The Magnetic Resonance in IMAGES (MR IMAGES) substudy investigated the effects of magnesium on the imaging surrogate outcome of infarct growth. METHODS IMAGES trial patients in participating centers were randomized to receive either intravenous magnesium or placebo within 12 hours of… CONTINUE READING

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