Results of the European Glaucoma Prevention Study.

@article{Miglior2005ResultsOT,
  title={Results of the European Glaucoma Prevention Study.},
  author={S. Miglior and T. Zeyen and N. Pfeiffer and J. Cunha-Vaz and V. Torri and I. Adamsons},
  journal={Ophthalmology},
  year={2005},
  volume={112 3},
  pages={
          366-75
        }
}
OBJECTIVE The European Glaucoma Prevention Study (EGPS) seeks to evaluate the efficacy of reduction of intraocular pressure (IOP) by dorzolamide in preventing or delaying primary open-angle glaucoma (POAG) in patients affected by ocular hypertension (OHT). DESIGN Randomized, double-masked, controlled clinical trial. PARTICIPANTS One thousand eighty-one patients (age, > or =30 years) were enrolled by 18 European centers. The patients fulfilled a series of inclusion criteria, including: IOP… Expand
Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study.
TLDR
Baseline age, vertical C/D ratio, vertical D ratio asymmetry, and PSD were good predictors of the onset of OAG in the EGPS and support the need for a thorough evaluation of patients with ocular hypertension. Expand
Central corneal thickness in the European Glaucoma Prevention Study.
TLDR
Central corneal thickness measurements within the EGPS were greater than those reported in other studies of normal eyes without ocular hypertension, and did not correlate with refraction, baseline IOP, or systemic hypertension. Expand
Intercurrent factors associated with the development of open-angle glaucoma in the European glaucoma prevention study.
TLDR
The need for future investigations to better elucidate the role of systemic diuretics in the development of OAG is suggested, because IOP and disk hemorrhages have already been shown to be important intercurrent factors in the Ocular Hypertension Treatment Study (OHTS) and Early Manifest Glaucoma Trial (EMGT). Expand
Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up
TLDR
The baseline parameters that proved to be useful in assessing the likelihood of an OHT patient to develop POAG included age, functional variables provided by SWAP, and structural variables providing by SLP and CSLO. Expand
Natural history of open-angle glaucoma.
TLDR
In this 6-year follow-up study, the median untreated rate of progression corresponded to advancing from normal visual function to blindness in approximately 70 years, whereas on the basis of the mean rate, visual function would show the same deterioration in approximately 25 years. Expand
The impact of intraocular pressure fluctuations and other factors on conversion of ocular hypertension to primary open-angle glaucoma
TLDR
The amount of fluctuation measured in the study sample did not result in the development of glaucoma in treated ocular hypertension patients, and myopia proved to be a risk factor. Expand
Predictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention study.
TLDR
Several baseline HRT parameters, alone or in combination with baseline clinical and demographic factors, were significantly associated with the development of open-angle glaucoma among the EGPS participants. Expand
Medical interventions for primary open angle glaucoma and ocular hypertension.
TLDR
The results of this review support the current practice of IOP lowering treatment of OHT and positive but weak evidence for a beneficial effect of the class of beta-blockers has been shown. Expand
Detecting Progression in Patients With Different Clinical Presentations of Primary Open-angle Glaucoma
TLDR
While both parameters showed comparable abilities to identify progression across the different classifications, RNFLT assessment may be better suited to monitor progression, particularly among patients with elevated intraocular pressure and those who present with only glaucomatous VF defect at baseline. Expand
Pattern ERG as an early glaucoma indicator in ocular hypertension: a long-term, prospective study.
TLDR
The pattern electroretinogram (PERG) can help to predict stability or progression to glaucoma in OHT at least 1 year ahead of conversion. Expand
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TLDR
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TLDR
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