Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption

@article{Rippke2001ResultsOP,
  title={Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption},
  author={F. Rippke and G. Wendt and K. Bohnsack and A. D{\"o}rschner and F. St{\"a}b and E. H{\"o}lzle and I. Moll},
  journal={Journal of Dermatological Treatment},
  year={2001},
  volume={12},
  pages={3 - 8}
}
BACKGROUND: UVA-induced photooxidation is considered to play an essential role in the pathogenesis of polymorphous light eruption (PLE), and topical pretreatment of skin with alpha-glucosylrutin (AGR), a potent plant-derived antioxidant, has been shown to significantly suppress photoprovoked PLE eruption. AIM: In order to further elucidate the optimum pretreatment regimen and to investigate the efficacy and skin compatibility of topical preparations containing AGR under field conditions, two… Expand
Impact of oral vitamin E supplementation on oxidative stress & lipid peroxidation in patients with polymorphous light eruption.
TLDR
Oxidative stress and differential modulation of antioxidant enzymes in PMLE might play a pathogenic role in humans, which supports the incorporation of antioxidant drugs in the treatment protocol of the disease. Expand
Prevention of polymorphic light eruption with a sunscreen of very high protection level against UVB and UVA radiation under standardized photodiagnostic conditions.
TLDR
It is demonstrated that a sunscreen with effective filters against UVA and UVB can successfully prevent the development of PLE. Expand
Treatment of polymorphic light eruption
TLDR
While sun protection, corticosteroids and desensitization phototherapy are the mainstays of management, a range of anti‐inflammatory and immunomodulatory agents are reported. Expand
Management of Polymorphous Light Eruption
TLDR
In the outpatient department, quality of life of most patients is improved with the treatment regimens that are recommended for patients with moderate-to-severe PLE, without the need for photo(chemo)therapy. Expand
Polymorphous light eruption (PLE) and a new potent antioxidant and UVA‐protective formulation as prophylaxis
TLDR
Polymorphous light eruption is the most common photodermatosis and its etiology seems to involve UVA‐induced oxidative stress and subsequent deregulation of antioxidative immune responses. Expand
High Levels of Free Radicals in Suncare Products Induce Acne Aestivalis in Sensitive Subjects
Cosmetic products may undergo oxidation, leading to rancidity, discoloration, and destabilization. This oxidation process can be minimized by the control of raw materials quality, preservation, andExpand
[Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress].
  • R. Wolber, F. Stäb, +5 authors K. Wittern
  • Chemistry, Medicine
  • Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2004
TLDR
All in vivo evaluations indicate that AGR in the applied concentrations is a very well-tolerated ingredient for medical skin care preparations. Expand
Sunscreen use in photodermatoses.
  • V. Deleo
  • Medicine
  • Dermatologic clinics
  • 2006
TLDR
Clinicians should recommend agents with avobenzones, benzophenones, and the physical blockers titanium oxides, as well as other agents available in other countries that offer better protection in patients with photodermatoses. Expand
Photoageing: mechanism, prevention and therapy
TLDR
Improved understanding of the skin’s innate UV protective mechanisms has also given rise to several novel treatment concepts that promise to revolutionize this field within the coming decade. Expand
Beyond sun protection factor testing
TLDR
There is a largely unrecognized need for testing of sunscreens against the condition known as polymorphic light eruption, a photosensitivity disorder estimated to affect a staggering 10–20% of the population in the northern hemisphere. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 16 REFERENCES
Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption.
TLDR
Evaluation after the 4th photoprovocation revealed that the development and severity of PLE and concomitant pruritus were significantly reduced by the application of distinct combinations of antioxidants. Expand
Systemic vitamin C and vitamin E do not prevent photoprovocation test reactions in polymorphous light eruption
TLDR
The antioxidants in the doses given and over the time period used did not influence the development of PLE, but might interfere with immunosuppressive effects of repeated photoprovocation tests. Expand
Controlled therapeutic trials in polymorphic light eruption
A series of controlled trials of treatments for polymorphic light eruption (PLE) with oral β‐carotene, ketoprofen and chloroquine, and topical benzimidazole sunscreen cream is described. ClinicalExpand
Catalase in the stratum corneum of patients with polymorphic light eruption.
TLDR
The diminished skin catalase in irradiated polymorphic light eruption makes it possible that a longer restoration time of catal enzyme is involved in the pathogenesis. Expand
Current aspects of polymorphous light eruptions in Sweden.
TLDR
PMLE is a common disorder and milder forms seem to be more prevalent than earlier described in northern countries such as Sweden, and they required rather high doses of sunlight to trigger their eruptions. Expand
A prospective longitudinal study of the outdoor behaviour and symptoms of photosensitive patients
TLDR
Tentative conclusions drawn from mathematical modelling indicated that the incidence of rash on a particular day was influenced by ambient ultraviolet radiation and length of time spent outdoors, whereas use of sunscreen may actually increase the likelihood of symptoms. Expand
Polymorphous light eruption: a common reaction uncommonly recognized.
TLDR
It is suggested that PMLE is a common disorder but that many individuals have a high threshold of response to sunlight exposure, and that there was one notable exception in the amount of sunlight required to trigger the eruption. Expand
Epidemiological studies of the influence of sunlight on the skin.
  • M. Berg
  • Medicine
  • Photo-dermatology
  • 1989
TLDR
The majority of subjects with atopic eczema, acne vulgaris or seborrheic dermatitis experienced improvement after Exposure to sunlight, and individuals with rosacea also experienced improvement more often than impairment from exposure to sunlight. Expand
Novel antioxidants : New strategies in product stabilization and skin protection
TLDR
The example of the flavonoid α-glucosyl rutin demonstrates that the phenolic antioxidants, which are highly efficacious in product protection, may not to be the first choice in skin protection. Expand
Epidemiological studies.
TLDR
The constructed prognosis model assumes an increase in the RC incidence among all population groups, which may cause the detection of 279 new cases by 2018; i.e. 16 cases more than in 2015. Expand
...
1
2
...