Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption

  title={Results of photoprovocation and field studies on the efficacy of a novel topically applied antioxidant in polymorphous light eruption},
  author={Frank Rippke and Guillaume Wendt and Kerstin Bohnsack and Albrecht D{\"o}rschner and Franz St{\"a}b and Erhard H{\"o}lzle and Ingrid Moll},
  journal={Journal of Dermatological Treatment},
  pages={3 - 8}
BACKGROUND: UVA-induced photooxidation is considered to play an essential role in the pathogenesis of polymorphous light eruption (PLE), and topical pretreatment of skin with alpha-glucosylrutin (AGR), a potent plant-derived antioxidant, has been shown to significantly suppress photoprovoked PLE eruption. AIM: In order to further elucidate the optimum pretreatment regimen and to investigate the efficacy and skin compatibility of topical preparations containing AGR under field conditions, two… 

Prevention of Polymorphic Light Eruption Afforded by a Very High Broad-Spectrum Protection Sunscreen Containing Ectoin

A high broad-spectrum sunscreen medical device, containing a very high protection complex of UVB and UVA filters and ectoin, was investigated for its ability to protect against UVA-induced PLE, and no positive PLE reaction was observed on the side of the chest treated by the test MD, whereaspositive PLE reactions were triggered on the untreated side of 13 subjects.

Impact of oral vitamin E supplementation on oxidative stress & lipid peroxidation in patients with polymorphous light eruption.

Oxidative stress and differential modulation of antioxidant enzymes in PMLE might play a pathogenic role in humans, which supports the incorporation of antioxidant drugs in the treatment protocol of the disease.

Prevention of polymorphic light eruption with a sunscreen of very high protection level against UVB and UVA radiation under standardized photodiagnostic conditions.

It is demonstrated that a sunscreen with effective filters against UVA and UVB can successfully prevent the development of PLE.

Treatment of polymorphic light eruption

While sun protection, corticosteroids and desensitization phototherapy are the mainstays of management, a range of anti‐inflammatory and immunomodulatory agents are reported.

Management of Polymorphous Light Eruption

In the outpatient department, quality of life of most patients is improved with the treatment regimens that are recommended for patients with moderate-to-severe PLE, without the need for photo(chemo)therapy.

Polymorphous light eruption (PLE) and a new potent antioxidant and UVA‐protective formulation as prophylaxis

Polymorphous light eruption is the most common photodermatosis and its etiology seems to involve UVA‐induced oxidative stress and subsequent deregulation of antioxidative immune responses.

High Levels of Free Radicals in Suncare Products Induce Acne Aestivalis in Sensitive Subjects

Cosmetic products may undergo oxidation, leading to rancidity, discoloration, and destabilization. This oxidation process can be minimized by the control of raw materials quality, preservation, and

[Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress].

  • R. WolberF. Stäb K. Wittern
  • Biology
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2004
All in vivo evaluations indicate that AGR in the applied concentrations is a very well-tolerated ingredient for medical skin care preparations.

Sunscreen use in photodermatoses.

  • V. Deleo
  • Medicine
    Dermatologic clinics
  • 2006

Photoageing: mechanism, prevention and therapy

Improved understanding of the skin’s innate UV protective mechanisms has also given rise to several novel treatment concepts that promise to revolutionize this field within the coming decade.



Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption.

Evaluation after the 4th photoprovocation revealed that the development and severity of PLE and concomitant pruritus were significantly reduced by the application of distinct combinations of antioxidants.

Systemic vitamin C and vitamin E do not prevent photoprovocation test reactions in polymorphous light eruption

The antioxidants in the doses given and over the time period used did not influence the development of PLE, but might interfere with immunosuppressive effects of repeated photoprovocation tests.

Controlled therapeutic trials in polymorphic light eruption

A series of controlled trials of treatments for polymorphic light eruption (PLE) with oral β‐carotene, ketoprofen and chloroquine, and topical benzimidazole sunscreen cream is described. Clinical

Catalase in the stratum corneum of patients with polymorphic light eruption.

The diminished skin catalase in irradiated polymorphic light eruption makes it possible that a longer restoration time of catal enzyme is involved in the pathogenesis.

Current aspects of polymorphous light eruptions in Sweden.

PMLE is a common disorder and milder forms seem to be more prevalent than earlier described in northern countries such as Sweden, and they required rather high doses of sunlight to trigger their eruptions.

A prospective longitudinal study of the outdoor behaviour and symptoms of photosensitive patients

Tentative conclusions drawn from mathematical modelling indicated that the incidence of rash on a particular day was influenced by ambient ultraviolet radiation and length of time spent outdoors, whereas use of sunscreen may actually increase the likelihood of symptoms.

Polymorphous light eruption: a common reaction uncommonly recognized.

It is suggested that PMLE is a common disorder but that many individuals have a high threshold of response to sunlight exposure, and that there was one notable exception in the amount of sunlight required to trigger the eruption.

Epidemiological studies of the influence of sunlight on the skin.

  • M. Berg
  • Medicine
  • 1989
The majority of subjects with atopic eczema, acne vulgaris or seborrheic dermatitis experienced improvement after Exposure to sunlight, and individuals with rosacea also experienced improvement more often than impairment from exposure to sunlight.

Novel antioxidants : New strategies in product stabilization and skin protection

The example of the flavonoid α-glucosyl rutin demonstrates that the phenolic antioxidants, which are highly efficacious in product protection, may not to be the first choice in skin protection.

Epidemiological studies.

The constructed prognosis model assumes an increase in the RC incidence among all population groups, which may cause the detection of 279 new cases by 2018; i.e. 16 cases more than in 2015.