Results of low-dose methotrexate treatment of persistent gestational trophoblastic disease in Sheffield 1980-1987.

@article{Dorreen1988ResultsOL,
  title={Results of low-dose methotrexate treatment of persistent gestational trophoblastic disease in Sheffield 1980-1987.},
  author={M. S. Dorreen and G. W. Pennington and D. R. Millar and Alex S. Hill and F. E. Neal},
  journal={Acta oncologica},
  year={1988},
  volume={27 5},
  pages={551-6}
}
Between January 1980 and October 1987, 115 evaluable patients were treated in Sheffield for persistent gestational trophoblastic disease (GTD) with a low dose methotrexate regimen (LD-MTX). Each course comprised MTX 50 mg given by i.m. injection for 4 doses on alternate days. Courses were repeated every 2 weeks and serum beta-hCG was used to monitor response. Overall, 80/115 (70%) of patients attained durable complete remissions (CR). Twenty-nine patients received the 'AVC' salvage combination… CONTINUE READING