Results of decitabine (5‐aza‐2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia

@article{Kantarjian2003ResultsOD,
  title={Results of decitabine (5‐aza‐2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia},
  author={Hagop M. Kantarjian and Susan O'brien and Jorge E. Cortes and Francis J. Giles and Stefan H. Faderl and Jean-Pierre J. Issa and Guillermo Garcia-Manero and Mary Beth Rios and Jianqin Shan and Michael Andreeff and Michael J. Keating and Moshe Talpaz},
  journal={Cancer},
  year={2003},
  volume={98}
}
General and site‐specific DNA methylation is associated with tumor progression and resistance in several cancers, including chronic myelogenous leukemia (CML). Decitabine is a hypomethylating agent that has shown encouraging preliminary anti‐CML activity. This study evaluated the activity and toxicity of decitabine in different phases of CML. 

Decitabine in chronic leukemias.

There is clear evidence of molecular (hypomethylation) as well as hematologic and cytogenetic responses to decitabine in chronic myelogenous leukemia of all phases, including in patients resistant to imatinib mesylate.

Phase II study of low‐dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia

A Phase II study was performed on low‐dose decitabine, a DNA methyltransferase inhibitor, in combination with imatinib in patients with CML in accelerated phase (AP) and myeloid blastic phase (BP).

Epigenetic therapy with decitabine for myelodysplasia and leukemia.

An overview of Decitabine with regard to the chemistry, pharmacokinetics and the data that support its role as the new therapeutic agent in leukemia and myelodysplastic syndrome is presented.

Decitabine improves patient outcomes in myelodysplastic syndromes

Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly

Decitabine: a historical review of the development of an epigenetic drug

The use of decitabine in MDS, AML, CML, stem cell transplant, sickle cell anemia and thalassemia looks promising, and the epigenetic dose seems lower than the cytotoxic dose.

Decitabine: a historical review of the development of an epigenetic drug

The use of decitabine in MDS, AML, CML, stem cell transplant, sickle cell anemia and thalassemia looks promising, and the epigenetic dose seems lower than the cytotoxic dose.

Demethylating agents in myeloid malignancies

Demethylating agents are the standard of care for patients with higher risk MDS and the only agent known to improve the natural history of MDS.

The use of hypomethylating agents in the treatment of hematologic malignancies

Postulated to work through hypomethylation of DNA causing induction of gene expression, the precise mechanism of action of these agents is not yet clear but future studies are likely to combine these agents with other drugs like the histone deacetylase inhibitors that act in related pathways.

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Based on analyses of preclinical and clinical data, low dose 5-AZA-CdR has the potential to be an effective form of therapy in some patients with cancer and novel dose schedules are proposed for investigation in patients withcancer.

Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer

It is shown that intensification of the DAC dose markedly increased its antineoplastic activity in mouse models of cancer, and there is a good correlation between the concentrations of DAC that reduce in vitro clonogenicity, reactivate TSGs and inhibit DNA methylation.
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