Results of a randomized trial of granulocyte colony-stimulating factor in patients with infection and severe granulocytopenia.

@article{Avils1996ResultsOA,
  title={Results of a randomized trial of granulocyte colony-stimulating factor in patients with infection and severe granulocytopenia.},
  author={Agust{\'i}n Avil{\'e}s and Renaldo Guzm{\'a}n and E. L{\'o}pez. Garc{\'i}a and Alejandra Talavera and Jos{\'e} C. D{\'i}az-Maqueo},
  journal={Anti-cancer drugs},
  year={1996},
  volume={7 4},
  pages={392-7}
}
A study was carried out to investigate the efficacy and toxicity of granulocyte colony-stimulating factor (G-CSF) in the treatment of infection in 119 severely granulocytopenic patients with hematological malignancies after intensive chemotherapy. Patients were assigned randomly to receive either antibiotics alone (ceftazidime, 2 g, i.v., every 8 h + amikacin 7.5 mg/kg, i.v., every 12 h) or the same antimicrobial regimen plus G-CSF (5 micrograms/kg/day, s.c.). Measurements were clinical… CONTINUE READING

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