Results of a phase I trial evaluating a liver support device utilizing albumin dialysis.

@article{Awad2001ResultsOA,
  title={Results of a phase I trial evaluating a liver support device utilizing albumin dialysis.},
  author={Samir S. Awad and Fresca C Swaniker and John L. Magee and Jeffrey Punch and Robert H. Bartlett},
  journal={Surgery},
  year={2001},
  volume={130 2},
  pages={354-62}
}
BACKGROUND We have previously reported the clearance of protein-bound and water-soluble hepatic toxins, in vitro and in an animal model, using albumin dialysis as an extracorporeal hepatic support (ECHS) device. OBJECTIVE The objective of this study was to evaluate albumin dialysis through a phase I clinical trial. We hypothesized that albumin dialysis would (1) decrease elevated levels of hepatic toxins, (2) increase the Fischer ratio, and (3) decrease hepatic encephalopathy (HES) and… CONTINUE READING