Results of a phase I/II clinical trial: standardized, non-xenogenic, cultivated limbal stem cell transplantation

  title={Results of a phase I/II clinical trial: standardized, non-xenogenic, cultivated limbal stem cell transplantation},
  author={Nadia Zakaria and Tine Possemiers and Sorcha N{\'i} Dhubhghaill and Inge Leysen and Jos J Rozema and C Koppen and Jean-Pierre Timmermans and Zwi Nisan Berneman and Marie-Jos{\'e} Tassignon},
  booktitle={Journal of Translational Medicine},
To determine if a standardized, non-xenogenic, reduced manipulation cultivation and surgical transplantation of limbal stem cell grafts is a safe and effective treatment option for patients with total and partial limbal stem cell deficiency. In vitro cellular outgrowth and phenotype of the limbal epithelial cell and composite grafts were validated using a new protocol. Patients received either autologous (n = 15) or allogenic (n = 3) explants cultured using a standardized protocol free from… CONTINUE READING
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