Results of a double-blind placebo-controlled study using ciprofloxacin for prevention of travelers' diarrhea

@article{Rademaker1989ResultsOA,
  title={Results of a double-blind placebo-controlled study using ciprofloxacin for prevention of travelers' diarrhea},
  author={Carin M. A. Rademaker and I. M. Hoepelman and Maurice J. H. M. Wolfhagen and H. M. Beumer and Maja Rozenberg-Arska and J. C. Barendrecht Verhoef},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={1989},
  volume={8},
  pages={690-694}
}
To determine the efficacy, safety and effect on fecal flora of ciprofloxacin in the prevention of travelers' diarrhea, 54 volunteers traveling to Tunisia were randomized in a double-blind manner to receive either 500 mg ciprofloxacin or a placebo once daily for one week. Results of 53 volunteers were available for evaluation of efficacy. One of 25 subjects (4%) receiving ciprofloxacin versus 18 of 28 subjects (64%) in the placebo group experienced travelers' diarrhea (p<0.0001). The protection… CONTINUE READING